Cavin-1: caveolae-dependent signalling and cardiovascular disease

Williams, J. J.L. and Palmer, T. M. (2014) Cavin-1: caveolae-dependent signalling and cardiovascular disease. Biochemical Society Transactions, 42(2), pp. 284-288. (doi: 10.1042/BST20130270) (PMID:24646232)

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Caveolae are curved lipid raft regions rich in cholesterol and sphingolipids found abundantly in vascular endothelial cells, adipocytes, smooth muscle cells and fibroblasts. They are multifunctional organelles with roles in clathrin-independent endocytosis, cholesterol transport, mechanosensing and signal transduction. Caveolae provide an environment where multiple receptor signalling components are sequestered, clustered and compartmentalized for efficient signal transduction. Many of these receptors, including cytokine signal transducer gp130 (glycoprotein 130), are mediators of chronic inflammation during atherogenesis. Subsequently, disruption of these organelles is associated with a broad range of disease states including cardiovascular disease and cancer. Cavin-1 is an essential peripheral component of caveolae that stabilizes caveolin-1, the main structural/integral membrane protein of caveolae. Caveolin-1 is an essential regulator of eNOS (endothelial nitric oxide synthase) and its disruption leads to endothelial dysfunction which initiates a range of cardiovascular and pulmonary disorders. Although dysfunctional cytokine signalling is also a hallmark of cardiovascular disease, knowledge of caveolae-dependent cytokine signalling is lacking as is the role of cavin-1 independent of caveolae. The present review introduces caveolae, their structural components, the caveolins and cavins, their regulation by cAMP, and their potential role in cardiovascular disease.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Palmer, Dr Timothy and Williams, Dr Jamie
Authors: Williams, J. J.L., and Palmer, T. M.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Biochemical Society Transactions
Publisher:Portland Press
ISSN (Online):1470-8752

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
500152Doctoral Training Grant 2009-15Timothy PalmerBiotechnology and Biological Sciences Research Council (BBSRC)BB/F016735/1RI CARDIOVASCULAR & MEDICAL SCIENCES
605941Extracellular signal-regulated kinase 5 (ERK5) and regulation of neuroendocrine differentiation in prostate cancerTimothy PalmerScottish Executive Health Department (SEHHD-CSO)ETM/226RI CARDIOVASCULAR & MEDICAL SCIENCES