Scopelliti, A., Cordero, J. B., Diao, F., Strathdee, K., White, B. H., Sansom, O. J. and Vidal, M. (2014) Local control of intestinal stem cell homeostasis by enteroendocrine cells in the adult Drosophila midgut. Current Biology, 24(11), pp. 1199-1211. (doi: 10.1016/j.cub.2014.04.007)
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Publisher's URL: http://dx.doi.org/10.1016/j.cub.2014.04.007
Abstract
Background: Enteroendocrine cells populate gastrointestinal tissues and are known to translate local cues into systemic responses through the release of hormones into the bloodstream.<p></p> Results: Here we report a novel function of enteroendocrine cells acting as local regulators of intestinal stem cell (ISC) proliferation through modulation of the mesenchymal stem cell niche in the <i>Drosophila</i> midgut. This paracrine signaling acts to constrain ISC proliferation within the epithelial compartment. Mechanistically, midgut enteroendocrine cells secrete the neuroendocrine hormone Bursicon, which acts—beyond its known roles in development—as a paracrine factor on the visceral muscle (VM). Bursicon binding to its receptor, DLGR2, the ortholog of mammalian leucine-rich repeat-containing G protein-coupled receptors (LGR4-6), represses the production of the VM-derived EGF-like growth factor Vein through activation of cAMP.<p></p> Conclusions: We therefore identify a novel paradigm in the regulation of ISC quiescence involving the conserved ligand/receptor Bursicon/DLGR2 and a previously unrecognized tissue-intrinsic role of enteroendocrine cells.<p></p>
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Vidal, Dr Marcos and Cordero, Professor Julia and Strathdee, Mrs Karen and Sansom, Professor Owen and Scopelliti, Mr Alessandro |
Authors: | Scopelliti, A., Cordero, J. B., Diao, F., Strathdee, K., White, B. H., Sansom, O. J., and Vidal, M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Current Biology |
Publisher: | Cell Press |
ISSN: | 0960-9822 |
ISSN (Online): | 1879-0445 |
Copyright Holders: | Copyright © 2014 The Authors |
First Published: | First published in Current Biology 24(11):1199-1211 |
Publisher Policy: | Reproduced under a Creative Commons License |
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