Yvon, C., Surman, A. J. , Hutin, M., Alex, J., Smith, B. O. , Long, D. L. and Cronin, L. (2014) Polyoxometalate clusters integrated into peptide chains and as inorganic amino acids: solution- and solid-phase approaches. Angewandte Chemie (International Edition), 53(13), pp. 3336-3341. (doi: 10.1002/anie.201311135)
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Abstract
General synthetic methods for the grafting of peptide chains onto polyoxometalate clusters by the use of general activated precursors have been developed. Using a solution-phase approach, pre-synthesized peptides can be grafted to a metal oxide cluster to produce hybrids of unprecedented scale (up to 30 residues). An adapted solid-phase method allows the incorporation of these clusters, which may be regarded as novel hybrid unnatural amino acids, during the peptide synthesis itself. These methods may open the way for the automated synthesis of peptides and perhaps even proteins that contain “inorganic” amino acids.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Hutin, Dr Marie and Yvon, Miss Carine and Smith, Dr Brian and Long, Dr Deliang and Cronin, Professor Lee and Surman, Dr Andrew |
Authors: | Yvon, C., Surman, A. J., Hutin, M., Alex, J., Smith, B. O., Long, D. L., and Cronin, L. |
College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences College of Science and Engineering > School of Chemistry |
Journal Name: | Angewandte Chemie (International Edition) |
Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA |
ISSN: | 1433-7851 |
ISSN (Online): | 1521-3773 |
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