Winder, S.J. (2003) Structural insights into actin-binding, branching and bundling proteins. Current Opinion in Cell Biology, 15, pp. 14-22. (doi: 10.1016/S0955-0674(02)00002-9)
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Abstract
Structural advances in our understanding of the functions of the actin cytoskeleton have come from diverse sources. On the one hand, the determination of the structure of a bacterial actin-like protein MreB reveals the prokaryotic origins of the actin cytoskeleton, whereas on the other, cryo-electron microscopy and crystallography have yielded reconstructions of many actin crosslinking, regulatory and binding proteins in complex with F-actin. Not least, a high-resolution structure of the Arp2/3 complex and a reconstruction with F-actin provides considerable insight into the eukaryotic machinery, vital for the formation of new F-actin barbed ends, a prerequisite for rapid actin polymerisation involved in cell shape change and motility.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | UNSPECIFIED |
| Authors: | Winder, S.J. |
| College/School: | College of Medical Veterinary and Life Sciences |
| Journal Name: | Current Opinion in Cell Biology |
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