Allan, K. , Masters, N., Rivers, S., Berry, K., Routh, A. and Lamm, C. (2014) T-lymphocyte-rich thymoma and myasthenia gravis in a Siberian tiger (Panthera tigris altaica). Journal of Comparative Pathology, 150(2-3), pp. 345-349. (doi: 10.1016/j.jcpa.2013.11.204)
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Abstract
A 10-year-old captive male Siberian tiger (Panthera tigris altaica) presented with acute onset collapse, vomiting and dyspnoea, preceded by a 6-month period of progressive muscle wasting. Following humane destruction, post-mortem examination revealed a large multilobulated mass in the cranial mediastinum, which was diagnosed as a T-lymphocyte-rich thymoma with the aid of immunohistochemistry. Retrospective serology for acetylcholine receptor antibodies (titre 3.90 nmol/l) confirmed a diagnosis of thymoma-associated myasthenia gravis. Thymomas are reported rarely in wild carnivores, but when detected they appear to be similar in morphology to those seen in domestic carnivores and may also be accompanied by paraneoplastic syndromes. The clinical signs of myasthenia gravis in the tiger were consistent with those reported in cats and dogs and the condition is proposed as an important differential diagnosis for generalized weakness in captive Felidae.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Allan, Dr Kathryn and Lamm, Dr Catherine |
| Authors: | Allan, K., Masters, N., Rivers, S., Berry, K., Routh, A., and Lamm, C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Journal of Comparative Pathology |
| Publisher: | Elsevier Ltd. |
| ISSN: | 0021-9975 |
| ISSN (Online): | 1532-3129 |
| Copyright Holders: | Copyright © 2013 The Authors |
| First Published: | First published in Journal of Comparative Pathology 150(2-3):345-349 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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