MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer

Valeri, N. et al. (2014) MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell, 25(4), pp. 469-483. (doi: 10.1016/j.ccr.2014.03.006) (PMID:24735923) (PMCID:PMC3995091)

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MicroRNA deregulation is frequent in human colorectal cancers (CRCs), but little is known as to whether it represents a bystander event or actually drives tumor progression in vivo. We show that miR-135b overexpression is triggered in mice and humans by APC loss, PTEN/PI3K pathway deregulation, and SRC overexpression and promotes tumor transformation and progression. We show that miR-135b upregulation is common in sporadic and inflammatory bowel disease-associated human CRCs and correlates with tumor stage and poor clinical outcome. Inhibition of miR-135b in CRC mouse models reduces tumor growth by controlling genes involved in proliferation, invasion, and apoptosis. We identify miR-135b as a key downsteam effector of oncogenic pathways and a potential target for CRC treatment.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Braconi, Professor Chiara and Ridgway, Dr Rachel and Valeri, Dr Nicola and Cordero, Professor Julia and Paulus-Hock, Mrs Viola and Murgia, Dr Claudio and Sansom, Professor Owen
Authors: Valeri, N., Braconi, C., Gasparini, P., Murgia, C., Lampis, A., Paulus-Hock, V., Hart, J. R., Ueno, L., Grivennikov, S. I., Lovat, F., Paone, A., Cascione, L., Sumani, K. M., Veronese, A., Fabbri, M., Carasi, S., Alder, H., Lanza, G., Gafa, R., Moyer, M. P., Ridgway, R. A., Cordero, J., Nuovo, G. J., Frankel, W. L., Rugge, M., Fassan, M., Groden, J., Vogt, P. K., Karin, M., Sansom, O. J., and Croce, C. M.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Cancer Cell
ISSN (Online):1878-3686
Copyright Holders:Copyright © 2014 Elsevier
First Published:First published in Cancer Cell 25(4):469-483
Publisher Policy:Reproduced under a Creative Commons License

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