Immunoradiometric assay of circulating C-reactive protein: age-related values in the adult general population

Hutchinson, W.L., Koenig, W., Frohlich, M., Sund, M., Lowe, G.D.O. and Pepys, M.B. (2000) Immunoradiometric assay of circulating C-reactive protein: age-related values in the adult general population. Clinical Chemistry, 46(7), pp. 934-938.

Abstract

Background: Increased values of C-reactive protein (CRP), the classical acute phase protein, within the range below 5 mg/L, previously considered to be within the reference interval, are strongly associated with increased risk of atherothrombotic events, and are clinically significant in osteoarthritis and neonatal infection.<br/> Methods: A robust new polyclonal-monoclonal solid-phase IRMA for CRP was developed, with a range of 0.05- 10.0 mg/L.<br/> Results: Plasma CRP values in general adult populations from Augsburg, Germany (2291 males and 2203 females; ages, 25-74 years) and Glasgow, Scotland (604 males and 650 females; ages, 25-64 years) were very similar. The median CRP approximately doubled with age, from similar to 1 mg/L in the youngest decade to similar to 2 mg/L in the oldest, and tended to be higher in females. <br/>Conclusion: This extensive data set, the largest such study of CRP, provides valuable reference information for future clinical and epidemiological investigations.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Lowe, Professor Gordon
• Authors: Hutchinson, W.L., Koenig, W., Frohlich, M., Sund, M., Lowe, G.D.O., and Pepys, M.B.
• Subjects: R Medicine > RB Pathology
• College/School: College of Medical Veterinary and Life Sciences; College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Clinical Chemistry
• Publisher: American Association for Clinical Chemistry
• ISSN: 0009-9147
• Copyright Holders: © Copyright 2003 American Association for Clinical Chemistry, Inc.
• First Published: First published in Clinical Chemistry 46(7):934-938
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher