Changes in anti-endotoxin-IgG antibody and endotoxaemia in three cases of gram-negative septic shock.

Barclay, G.R., Scott, B.B., Wright, I.H., Rogers, P.N., Smith, D.G. and Poxton, I.R. (1989) Changes in anti-endotoxin-IgG antibody and endotoxaemia in three cases of gram-negative septic shock. Circulatory Shock, 29(2), pp. 93-106.

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Abstract

Circulating endotoxin levels and IgG antibodies to a range of Gram-negative bacterial lipopolysaccharides (LPS) (endotoxins) of different sizes and structures were measured daily in three cases of septic shock. There was an inverse relationship between endotoxin levels and cross-reactive antibodies to the core glycolipid (CGL) region of lipopolysaccharide. This suggests that antibody to LPS-CGL was initially consumed by a superabundance of endotoxin, and that a resurgence of intrinsic anti-LPS-CGL antibody levels may be associated with a reduction of circulating endotoxin. The implications of these findings for passive antibody therapy of septic shock are discussed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Smith, Professor David
Authors: Barclay, G.R., Scott, B.B., Wright, I.H., Rogers, P.N., Smith, D.G., and Poxton, I.R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Circulatory Shock
ISSN:0092-6213
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