Tomavo, S., Slomianny, C., Meissner, M. and Carruthers, V.B. (2013) Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion. PLoS Pathogens, 9(10), e1003629. (doi: 10.1371/journal.ppat.1003629)
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Abstract
Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites are essential for successful host infection. New findings reveal that the contents of these organelles, which are transported through the endoplasmic reticulum (ER) and Golgi, also require the parasite endosome-like system to access their respective organelles. In this review, we discuss recent findings that demonstrate that these parasites reduced their endosomal system and modified classical regulators of this pathway for the biogenesis of apical organelles.
| Item Type: | Articles |
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| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Meissner, Professor Markus |
| Authors: | Tomavo, S., Slomianny, C., Meissner, M., and Carruthers, V.B. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | PLoS Pathogens |
| Publisher: | Public Library of Science |
| ISSN: | 1553-7366 |
| ISSN (Online): | 1553-7374 |
| Copyright Holders: | Copyright © 2013 The Authors |
| First Published: | First published in PLoS Pathogens 9(10):e1003629 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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