Lawsonia intracellularis: getting inside the pathogenesis of proliferative enteropathy

Smith, D.G.E. and Lawson, G.H.K. (2001) Lawsonia intracellularis: getting inside the pathogenesis of proliferative enteropathy. Veterinary Microbiology, 82(4), pp. 331-345. (doi: 10.1016/S0378-1135(01)00397-2)

Abstract

Although proliferative enteropathy (PE) has been recognised for several decades, <i>Lawsonia intracellularis</i>, the aetiological agent, was identified formally in only 1995. This organism is both highly fastidious and obligately intracellular bacterium, characteristics which have inevitably restricted investigations in all aspects of its biology. Despite these limitations, advances have been made in characterising and understanding <i>L. Intracellularis</i>-host interaction both <i>in vivo</i> and <i>in vitro</i>. Based upon evidence provided by mainly pathological and histological investigations conducted to date, we review salient features of our current understanding of processes involved throughout the course of infection by this unique pathogen.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Smith, Professor David
• Authors: Smith, D.G.E., and Lawson, G.H.K.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Veterinary Microbiology
• ISSN: 0378-1135