Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: ‘designer’ changes in Vmax, stability and membrane association

Houslay, M.D. et al. (1995) Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: ‘designer’ changes in Vmax, stability and membrane association. Biochemical Society Transactions, 23, pp. 393-398.

Abstract

Abbreviations used: cAMP, cyclic AMP; PKA, cAMP-dependent protein kinase; PDE, phosphodiesterase; Met26-RD1, RD1 lacking the N-terminal 25 amino acids; CAT, chloramphenical acetyltransferase.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Houslay, Professor Miles and Michie, Professor Alison and Tobias, Professor Edward
• Authors: Houslay, M.D., Scotland, G., Pooley, L., Spence, S., Wilkinson, I., McCallum, F., Julien, P., Rena, N.G., Michie, A.M., Erdogan, S., Zeng, L., O'Connell, J.C., Tobias, E.S., and MacPhee, I.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences; College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Biochemical Society Transactions
• ISSN: 0300-5127
• ISSN (Online): 1470-8752