McMillan, L. E.M. and Martin, A. C.R. (2008) Automatically extracting functionally equivalent proteins from SwissProt. BMC Bioinformatics, 9, p. 418. (doi: 10.1186/1471-2105-9-418)
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Publisher's URL: http://dx.doi.org/10.1186/1471-2105-9-418
Abstract
In summary, FOSTA provides an automated analysis of annotations in UniProtKB/Swiss-Prot to enable groups of proteins already annotated as functionally equivalent, to be extracted. Our results demonstrate that the vast majority of UniProtKB/Swiss-Prot functional annotations are of high quality, and that FOSTA can interpret annotations successfully. Where FOSTA is not successful, we are able to highlight inconsistencies in UniProtKB/Swiss-Prot annotation. Most of these would have presented equal difficulties for manual interpretation of annotations. We discuss limitations and possible future extensions to FOSTA, and recommend changes to the UniProtKB/Swiss-Prot format, which would facilitate text-mining of UniProtKB/Swiss-Prot.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Hopcroft, Dr Lisa |
Authors: | McMillan, L. E.M., and Martin, A. C.R. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | BMC Bioinformatics |
Publisher: | Biomed Central |
ISSN: | 1471-2105 |
Copyright Holders: | Copyright © 2008 The Authors |
First Published: | First published in BMC Bioinformatics 9:418 |
Publisher Policy: | Reproduced under a Creative Commons License |
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