A new model for coenzyme B12 based on a Costa-type ligand

Altink, R., van Arkel, B., van der Baan, J.L., Balt, S., De Bolster, M.W.G., van Delft, R.J., Klumpp, G.W., De Koning, H. and van den Winkel, Y. (2010) A new model for coenzyme B12 based on a Costa-type ligand. Recueil des Travaux Chimiques des Pays-Bas, 113(6), pp. 329-333. (doi: 10.1002/recl.19941130604)

Abstract

The synthesis of a new Costa-type ligand (H2mdo), in which the propylene bridge has been replaced by a methylenedioxy bridge has been accomplished: two molecules of butanedione monoxime are coupled via a CH2 group by reaction with CH2Cl2 and 50% aqueous NaOH in the presence of a phase-transfer reagent. Dihalidocobalt and alkyl(halido)cobalt complexes of the deprotonated ligand have been prepared and structurally characterized by NMR spectroscopy.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: De Koning, Professor Harry
• Authors: Altink, R., van Arkel, B., van der Baan, J.L., Balt, S., De Bolster, M.W.G., van Delft, R.J., Klumpp, G.W., De Koning, H., and van den Winkel, Y.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Recueil des Travaux Chimiques des Pays-Bas
• ISSN: 0165-0513