IL-21 receptor expression in human tendinopathy

Campbell, A. L., Smith, N. C., Reilly, J. H., Kerr, S. C., Leach, W. J., Fazzi, U. G., Rooney, B. P., Murrell, G. A.C. and Millar, N. L. (2014) IL-21 receptor expression in human tendinopathy. Mediators of Inflammation, 2014(481206), pp. 1-7. (doi: 10.1155/2014/481206)

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The pathogenetic mechanisms underlying tendinopathy remain unclear, with much debate as to whether inflammation or degradation has the prominent role. Increasing evidence points toward and early inflammatory infiltrate and associated inflammatory cytokine production in human and animal models of tendon disease. The IL-21/IL-21R axis is a proinflammatory cytokine complex that has been associated with chronic inflammatory diseases including rheumatoid arthritis and inflammatory bowel disease. This project aimed to investigate the role and expression of the cytokine/receptor pair IL-21/IL-21R in human tendinopathy. We found significantly elevated expression of IL-21 receptor message and protein in human tendon samples but found no convincing evidence of the presence of IL-21 at message or protein level. The level of expression of IL-21R message/protein in human tenocytes was significantly up regulated by proinflammatory cytokines (TNFα/IL-1β) in vitro. These findings demonstrate that IL-21R is present in early human tendinopathy mainly expressed by tenocytes and macrophages. Despite a lack of IL-21 expression these data again suggest that early tendinopathy has an inflammatory/cytokine phenotype, which may provide novel translational targets in the treatment of tendinopathy.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Reilly, Mr James and Millar, Professor Neal and Kerr, Mrs Shauna and Fazzi, Mr Umberto
Authors: Campbell, A. L., Smith, N. C., Reilly, J. H., Kerr, S. C., Leach, W. J., Fazzi, U. G., Rooney, B. P., Murrell, G. A.C., and Millar, N. L.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Mediators of Inflammation
Publisher:Hindawi Publishing Corporation
ISSN (Online):1466-1861
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in Mediators of Inflammation 2014(481206):1-7
Publisher Policy:Reproduced under a Creative Commons License
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
620681The role of microRNA 29 in tendon diseaseNeal MillarWellcome Trust (WELLCOME)100651/Z/12/ZIII -IMMUNOLOGY