Phesse, T. J. and Sansom, O. J. (2013) Responding to R-Spondin: Slit2 potentiates intestinal regeneration. Cell Stem Cell, 13(5), pp. 512-514. (doi: 10.1016/j.stem.2013.10.006)
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Abstract
Gastrointestinal toxicity of chemoradiotherapy treatment in late-stage cancer patients limits tolerable doses and effectiveness of treatments. Zhou and colleagues in Nature ( Zhou et al., 2013) suggest that activating Robo/Slit signaling in concert with R-Spondin potentiates Wnt signaling in intestinal stem cells and drives successful intestinal regeneration and recovery.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Sansom, Professor Owen |
| Authors: | Phesse, T. J., and Sansom, O. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Cell Stem Cell |
| ISSN: | 1934-5909 |
| ISSN (Online): | 1875-9777 |
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