Frantzi, M. et al. (2014) Discovery and validation of urinary biomarkers for detection of renal cell carcinoma. Journal of Proteomics, 98C, pp. 44-58. (doi: 10.1016/j.jprot.2013.12.010)
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Abstract
Clear cell renal cell carcinoma (RCC) has the highest incidence among the renal malignancies, often presenting non-specific or no symptoms at all. Moreover, with no diagnostic marker being available so far, almost 30% of the patients are diagnosed with metastatic disease and 30-40% of the patients initially diagnosed with localized tumor relapse. These facts introduce the clinical need of early diagnosis. This study is focused on the investigation of a marker model based on urinary peptides, as a tool for the detection of RCC in selected patients at risk. Upon evaluation of the marker model in an independent blinded set of 76 samples, 80% sensitivity and 87% specificity were reported. An additional dataset of 1077 samples was subsequently employed for further evaluation of the specificity of the classifier.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Mullen, Dr Bill and Husi, Dr Holger and Mischak, Professor Harald |
Authors: | Frantzi, M., Metzger, J., Banks, R. E., Husi, H., Klein, J., Dakna, M., Mullen, W., Cartledge, J. J., Schanstra, J. P., Brand, K., Kuczyk, M. A., Mischak, H., Vlahou, A., Theodorescu, D., and Merseburger, A. S. |
Subjects: | Q Science > QH Natural history > QH345 Biochemistry R Medicine > R Medicine (General) |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | Journal of Proteomics |
ISSN: | 1874-3919 |
ISSN (Online): | 1876-7737 |
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