Quantitative mass spectrometry-based proteomics in angiogenesis

Hernandez, J.R., Reid, S.E., Neilson, L.J. and Zanivan, S. (2013) Quantitative mass spectrometry-based proteomics in angiogenesis. Proteomics Clinical Applications, 7(7-8), pp. 464-476. (doi: 10.1002/prca.201200055)

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The process of new blood vessel formation from pre-existing ones is called angiogenesis. Beyond playing a critical role in the physiological development of the vascular system, angiogenesis is a well-recognised hallmark of cancer. Unbiased system-wide approaches are required to complement the current knowledge, and intimately understand the molecular mechanisms regulating this process in physiological and pathological conditions. In this review we describe the cellular and molecular dynamics regulating the physiological growth of vessels and their deregulation in cancer, survey in vitro and in vivo models currently exploited to investigate various aspects of angiogenesis and describe state-of-the-art and most widespread methods and technologies in MS shotgun proteomics. Finally, we focus on current applications of MS to better understand endothelial cell behaviour and propose how modern proteomics can impact on angiogenesis research.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Zanivan, Professor Sara and Hernandez, Dr Juan and Neilson, Ms Lisa
Authors: Hernandez, J.R., Reid, S.E., Neilson, L.J., and Zanivan, S.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Proteomics Clinical Applications
ISSN (Online):1862-8354

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