The phase of thalamic alpha activity modulates cortical gamma-band activity: evidence from resting-state MEG recordings

Roux, F., Wibral, M., Singer, W., Aru, J. and Uhlhaas, P.J. (2013) The phase of thalamic alpha activity modulates cortical gamma-band activity: evidence from resting-state MEG recordings. Journal of Neuroscience, 33(45), pp. 17827-17835. (doi:10.1523/JNEUROSCI.5778-12.2013)

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Abstract

Recent findings have implicated thalamic alpha oscillations in the phasic modulation of cortical activity. However, the precise relationship between thalamic alpha oscillations and neocortical activity remains unclear. Here we show in a large sample of healthy human participants (n = 45) using spatial filtering techniques and measures of phase amplitude coupling that the amplitude of gamma-band activity in posterior medial parietal cortex is modulated by the phase of thalamic alpha oscillations during eyes-closed resting-state recordings. In addition, our findings show that gamma-band activity in visual cortex was not modulated by thalamic alpha oscillations but coupled to the phase of strong cortical alpha activity. To overcome the limitations of electromagnetic source localization we estimated conduction delays using transfer entropy and found nonspurious information transfer from thalamus to cortex. The present findings provide novel evidence for magneto-encephalography-measured phase coupling between cortical gamma-band activity and thalamic alpha oscillations, which highlight the role of phasic inhibition in the coordination of cortical activity.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Uhlhaas, Professor Peter
Authors: Roux, F., Wibral, M., Singer, W., Aru, J., and Uhlhaas, P.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Journal of Neuroscience
ISSN:0270-6474
ISSN (Online):1529-2401

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