Frampton, M. et al. (2013) Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin’s lymphoma. Nature Communications, 4, (doi: 10.1038/ncomms3549)
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Abstract
n addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin’s lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background), and follow-up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P=1.14 × 10−12, odds ratio (OR)=1.26) and 6q23.3 (rs7745098; P=3.42 × 10−9, OR=1.21). rs3806624 localizes 5′ to the EOMES (eomesodermin) gene within a p53 response element affecting p53 binding. rs7745098 maps intergenic to HBS1L and MYB, a region previously associated with haematopoiesis. These findings provide further insight into the genetic and biological basis of inherited susceptibility to HL.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Jarrett, Professor Ruth and Lake, Ms Annette and Montgomery, Mrs Dorothy |
Authors: | Frampton, M., da Silva Filho, M.I., Broderick, P., Thomsen, H., Försti, A., Vijayakrishnan, J., Cooke, R., Enciso-Mora, V., Hoffmann, P., Nöthen, M.M., Lloyd, A., Holroyd, A., Eisele, L., Jöckel, K., Ponader, S., von Strandmann, E.P., Lightfoot, T., Roman, E., Lake, A., Montgomery, D., Jarrett, R.F., Swerdlow, A.J., Engert, A., Hemminki, K., and Houlston, R.S. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
Journal Name: | Nature Communications |
Publisher: | Nature Publishing Group |
ISSN: | 2041-1723 |
ISSN (Online): | 2041-1723 |
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