The human urinary proteome fingerprint database UPdb

Husi, H., Barr, J.B., Skipworth, R.J.E., Stephens, N., Greig, C.A., Wackerhage, H., Barron, R., Fearon, K.C.H. and Ross, J.A. (2013) The human urinary proteome fingerprint database UPdb. International Journal of Proteomics, 2013(760208), (doi:10.1155/2013/760208)

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Abstract

The use of human urine as a diagnostic tool has many advantages, such as ease of sample acquisition and noninvasiveness. However, the discovery of novel biomarkers, as well as biomarker patterns, in urine is hindered mainly by a lack of comparable datasets. To fill this gap, we assembled a new urinary fingerprint database. Here, we report the establishment of a human urinary proteomic fingerprint database using urine from 200 individuals analysed by SELDI-TOF (surface enhanced laser desorption ionisation-time of flight) mass spectrometry (MS) on several chip surfaces (SEND, HP50, NP20, Q10, CM10, and IMAC30). The database currently lists 2490 unique peaks/ion species from 1172 nonredundant SELDI analyses in the mass range of 1500 to 150000. All unprocessed mass spectrometric scans are available as ".xml" data files. Additionally, 1384 peaks were included from external studies using CE (capillary electrophoresis)-MS, MALDI (matrix assisted laser desorption/ionisation), and CE-MALDI hybrids. We propose to use this platform as a global resource to share and exchange primary data derived from MS analyses in urinary research.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Husi, Dr Holger
Authors: Husi, H., Barr, J.B., Skipworth, R.J.E., Stephens, N., Greig, C.A., Wackerhage, H., Barron, R., Fearon, K.C.H., and Ross, J.A.
Subjects:Q Science > QH Natural history > QH301 Biology
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:International Journal of Proteomics
Publisher:Hindawi Publishing Corporation
ISSN:2090-2166
ISSN (Online):2090-2174
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in the International Journal of Proteomics 2013(760208)
Publisher Policy:Reproduced under a Creative Commons License

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