Gunawardana, L., Smith, G.D., Zammit, S., Whitley, E. , Gunnell, D., Lewis, S. and Rasmussen, F. (2011) Pre-conception inter-pregnancy interval and risk of schizophrenia. British Journal of Psychiatry, 199(4), pp. 338-339. (doi: 10.1192/bjp.bp.111.092916)
Full text not currently available from Enlighten.
Abstract
It is hypothesised that the risk of schizophrenia may be elevated in children conceived following a short inter-pregnancy interval, when maternal folate stores are still being replenished. We examined the relationship between inter-pregnancy interval and schizophrenia risk in a longitudinal, population-based cohort. Risk of schizophrenia was increased by approximately 150% in those born following a pregnancy interval of ≤6 months, but was not increased if the interval after birth of the participant, before conception of the subsequent sibling, was ≤6 months. These findings support the hypothesis that folate (or other micronutrient) deficiency during fetal development may be an important risk factor for schizophrenia.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Whitley, Dr Elise |
Authors: | Gunawardana, L., Smith, G.D., Zammit, S., Whitley, E., Gunnell, D., Lewis, S., and Rasmussen, F. |
College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > MRC/CSO SPHSU |
Journal Name: | British Journal of Psychiatry |
ISSN: | 0007-1250 |
ISSN (Online): | 1472-1465 |
University Staff: Request a correction | Enlighten Editors: Update this record