Serum-treated antigen-antibody complexes inhibit the production of C2 and factor B by mononuclear phagocytes

Whaley, K., Lappin, D. and Hamilton, A.O. (1983) Serum-treated antigen-antibody complexes inhibit the production of C2 and factor B by mononuclear phagocytes. Immunology, 48(2), pp. 255-263.

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Abstract

Antigen-antibody complexes enhanced the synthesis of C2 and factor B by human monocytes and macrophages, and C2 by guinea-pig macrophages. In contrast complexes that had been treated with serum inhibited the production of these components. The inhibitory effect of serum-treated complexes was abrogated by Fab fragments of anti-C3, anti-C3c and anti-C3d. It is therefore probable that inhibition was mediated by a C3 fragment bound to the complex. The enhancing effect of untreated complexes was reversible by serum-treated complexes, and the inhibitory action of serum-treated complexes was counteracted by untreated complexes. Such a system may be important in the regulation of the synthesis of complement components in response to local requirements.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Lappin, Dr David
Authors: Whaley, K., Lappin, D., and Hamilton, A.O.
Subjects:Q Science > QR Microbiology > QR180 Immunology
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Immunology
ISSN:0019-2805
ISSN (Online):1365-2567
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