Whaley, K., Lappin, D. and Hamilton, A.O. (1983) Serum-treated antigen-antibody complexes inhibit the production of C2 and factor B by mononuclear phagocytes. Immunology, 48(2), pp. 255-263.
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Abstract
Antigen-antibody complexes enhanced the synthesis of C2 and factor B by human monocytes and macrophages, and C2 by guinea-pig macrophages. In contrast complexes that had been treated with serum inhibited the production of these components. The inhibitory effect of serum-treated complexes was abrogated by Fab fragments of anti-C3, anti-C3c and anti-C3d. It is therefore probable that inhibition was mediated by a C3 fragment bound to the complex. The enhancing effect of untreated complexes was reversible by serum-treated complexes, and the inhibitory action of serum-treated complexes was counteracted by untreated complexes. Such a system may be important in the regulation of the synthesis of complement components in response to local requirements.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Lappin, Dr David |
Authors: | Whaley, K., Lappin, D., and Hamilton, A.O. |
Subjects: | Q Science > QR Microbiology > QR180 Immunology |
College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School |
Journal Name: | Immunology |
ISSN: | 0019-2805 |
ISSN (Online): | 1365-2567 |
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