Synthesis of complement components by synovial membrane

Whaley, K., Guc, D., Gulati, P. and Lappin, D. (1992) Synthesis of complement components by synovial membrane. Immunopharmacology, 24(2), pp. 83-89. (doi:10.1016/0162-3109(92)90014-4)

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The plasma levels of most ccmflement compo- nents are maintained by hepatic synthesis (Alper et al., 1969; Cohen, 1976). The nepatocyte is the cell responsible. as shown by studies on the primary cultures of rat and mouse hepatocytes and by studying synthesis of complement com- ponents by hepatocellular carcinoma cell lines such as Hep-3b and Hcp-G2 (Morris et al., 1982a). The most notable exceptions to this rule are Clq, Factor D and properdin. Studies on the acute phase response have shown that comple- ment proteins are acute phase proteins, with increased hcpatocyte synthesis occurring in re- sponse to cytokines such as interleukin 1 (IL-l), interleukin 6 (IL-6), tumour necrosis factor-a and interferon-y (Miura et al., 1987; Andus et al., 1988; Rarnadori et al., 1988; Anthony et al., 1989). Synthesis of complement proteins also occurs in edrahepatic sites. To date it has been shown that all nwima! tissues are able to synthesize at least one complement component [Ruddy and Correspondence to: K. Whdey, Department of Immunology, Leicester Royal Infirmary. Leicester. LEI 5WW. UK Cohen, 1974). In addition, synthesis of comple- ment components occurs in chronically inflamed tissues such as the rheumatoid joint (Moffat et al., 1989). A large number of differem cell types have been shown to synthesize complement com- ponents (Table I). These include mononuclear phagocytes, fibroblasts, endothehal ceils, eplthe- lial cells, alveolar type 2 epithelial cells and adipocytes (Colten, 1976; Morris et al., 1982a; Cook et al., 1987; Cole and Coltzn, 19ir8).

Item Type:Articles
Glasgow Author(s) Enlighten ID:Lappin, Dr David
Authors: Whaley, K., Guc, D., Gulati, P., and Lappin, D.
Subjects:Q Science > QR Microbiology > QR180 Immunology
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Immunopharmacology

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