TMS over V5 disrupts motion prediction

Vetter, P., Grosbras, M.-H. and Muckli, L. (2015) TMS over V5 disrupts motion prediction. Cerebral Cortex, 25(4), pp. 1052-1059. (doi: 10.1093/cercor/bht297) (PMID:24152544) (PMCID:PMC4380002)

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Given the vast amount of sensory information the brain has to deal with, predicting some of this information based on the current context is a resource-efficient strategy. The framework of predictive coding states that higher-level brain areas generate a predictive model to be communicated via feedback connections to early sensory areas. Here, we directly tested the necessity of a higher-level visual area, V5, in this predictive processing in the context of an apparent motion paradigm. We flashed targets on the apparent motion trace in-time or out-of-time with the predicted illusory motion token. As in previous studies, we found that predictable in-time targets were better detected than unpredictable out-of-time targets. However, when we applied functional magnetic resonance imaging-guided, double-pulse transcranial magnetic stimulation (TMS) over left V5 at 13–53 ms before target onset, the detection advantage of in-time targets was eliminated; this was not the case when TMS was applied over the vertex. Our results are causal evidence that V5 is necessary for a prediction effect, which has been shown to modulate V1 activity (Alink et al. 2010). Thus, our findings suggest that information processing between V5 and V1 is crucial for visual motion prediction, providing experimental support for the predictive coding framework.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Muckli, Professor Lars and Grosbras, Dr Marie-Helene and Vetter, Dr Petra
Authors: Vetter, P., Grosbras, M.-H., and Muckli, L.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Cerebral Cortex
ISSN (Online):1460-2199
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in Cerebral Cortex 25(4):1052-1059
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
474481Brain processes predicting forthcoming perception - cortical feedback and visual predictionsLars MuckliBiotechnology and Biological Sciences Research Council (BBSRC)BB/G005044/1INP - CENTRE FOR COGNITIVE NEUROIMAGING