Reddy, P.G., Pratap, T.V., Kumar, G.D.K., Mohanty, S.K. and Baskaran, S. (2002) The Lindlar catalyst revitalized: a highly chemoselective method for the direct conversion of azides to N-(tert-butoxycarbonylamines. European Journal of Organic Chemistry, 2002(22), pp. 3740-3743. (doi: 10.1002/1099-0690(200211)2002:22<3740::AID-EJOC3740>3.0.CO;2-5)
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Publisher's URL: http://dx.doi.org/10.1002/1099-0690(200211)2002:22<3740::AID-EJOC3740>3.0.CO;2-5
Abstract
An exceptionally chemoselective method for the direct conversion of azides to N-(tert-butoxycarbonyl)-protected amines under catalytic transfer-hydrogenation conditions, using the Lindlar catalyst, is reported. The extremely labile functional groups such as N-Cbz, benzyl ester are shown to be inert under the reaction conditions. The present method allows us to synthesize orthogonally protected (N-Cbz & N-Boc) 1,2-diamino systems, which will be immensely useful in organic synthesis.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Gaddale Devanna, Dr Kishore Kumar |
| Authors: | Reddy, P.G., Pratap, T.V., Kumar, G.D.K., Mohanty, S.K., and Baskaran, S. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | European Journal of Organic Chemistry |
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA |
| ISSN: | 1434-193X |
| ISSN (Online): | 1099-0690 |
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