Senescence at a glance

Pawlikowski, J.S., Adams, P.D. and Nelson, D.M. (2013) Senescence at a glance. Journal of Cell Science, 126(18), pp. 4061-4067. (doi: 10.1242/jcs.109728) (PMID:23970414) (PMCID:PMC3772382)

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Cellular senescence is a stable proliferation arrest that is associated with extensive cellular remodelling and an altered secretory pathway. Through its numerous inducers that lead to altered gene expression, senescence is able to influence many contrasting functions and pathologies, namely tumour suppression, tumour promotion, wound healing and ageing. As senescence is able to control such important tissue functions, it is now being pinpointed as a possible route for novel therapies. This article and accompanying poster aim to provide a summary of the initiators, pathways and roles of senescence, as well as present examples of senescence and a possible use for senescence in therapy.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Pawlikowski, Mr Jeff and Nelson, Mr David and Adams, Professor Peter
Authors: Pawlikowski, J.S., Adams, P.D., and Nelson, D.M.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Journal of Cell Science
ISSN (Online):1477-9137

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
495301Tumor progression - its antagonistic regulation by Wnt-signalling and oncogene-induced senescence.Peter AdamsCancer Research UK (CAN-RES-UK)C10652/A10250RI CANCER SCIENCES