Step-economic synthesis of (+)-crocacin C: a concise crotylboronation/[3,3]-sigmatropic rearrangement approach

Pasqua, A.E., Ferrari, F.D., Hamman, C., Liu, Y., Crawford, J.J. and Marquez, R. (2012) Step-economic synthesis of (+)-crocacin C: a concise crotylboronation/[3,3]-sigmatropic rearrangement approach. Journal of Organic Chemistry, 77(16), pp. 6989-6997. (doi: 10.1021/jo301210f)

Abstract

The step-economic total synthesis of (+)-crocacin C has been achieved in 20% yield from commercially available starting materials. This approach requires the isolation of only 8 intermediates and can provide a reliable supply of (+)-crocacin C for the development of new antifungal and crop protection agents.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Marquez, Dr Rudi and Ferrari, Mr Frank
• Authors: Pasqua, A.E., Ferrari, F.D., Hamman, C., Liu, Y., Crawford, J.J., and Marquez, R.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Journal of Organic Chemistry
• ISSN: 0022-3263
• ISSN (Online): 1520-6904