Protein and nucleic acid analyses of influenza C viruses isolated from pigs and man

Elliott, R.M., Yuanji, G. and Desselberger, U. (1985) Protein and nucleic acid analyses of influenza C viruses isolated from pigs and man. Vaccine, 3(3), pp. 182-188. (doi: 10.1016/0264-410X(85)90100-8)

Abstract

The virus-coded proteins and the genomes of influenza C virus isolates obtained from Chinese pigs in 1981–1982 and of human influenza C virus strains isolated between 1947 and 1981 were compared. Using SDS polyacrylamide gel electrophoresis and one-dimensional peptide mapping we found the virus-coded proteins of the pig influenza C viruses to be similar to those of human influenza C virus strains. The sizes of the genomes of human and pig influenza C viruses were indistinguishable. Genome analysis by oligonucleotide (ON) mapping revealed that the genomes of the pig influenza C viruses were very similar to but not identical with those of human influenza C virus strains. ON changes were found scattered over the whole genome. ON mapping of isolated segments of several influenza C virus strains suggested that two pig strains (C/P/B/10/81 and C/P/B/32/81) are related by a reassortment event which is likely to have occurred in nature. The rate of genome variation in influenza C viruses seemed to be similar to that seen in influenza B, and slower than that recorded for influenza A viruses.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Elliott, Professor Richard
• Authors: Elliott, R.M., Yuanji, G., and Desselberger, U.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Vaccine
• ISSN: 0264-410X
• ISSN (Online): 1873-2518