Maiques, E., Ubeda, C., Campoy, S., Salvador, N., Lasa, I., Novick, R.P., Barbe, J. and Penades, J.R. (2006) β-Lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in staphylococcus aureus. Journal of Bacteriology, 188(7), pp. 2726-2729. (doi: 10.1128/JB.188.7.2726-2729.2006)
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Abstract
Antibiotics that interfere with DNA replication and cell viability activate the SOS response. In Staphylococcus aureus, the antibiotic-induced SOS response promotes replication and high-frequency horizontal transfer of pathogenicity island-encoded virulence factors. Here we report that β-lactams induce a bona fide SOS response in S. aureus, characterized by the activation of the RecA and LexA proteins, the two master regulators of the SOS response. Moreover, we show that β-lactams are capable of triggering staphylococcal prophage induction in S. aureus lysogens. Consequently, and as previously described for SOS induction by commonly used fluoroquinolone antibiotics, β-lactam-mediated phage induction also resulted in replication and high-frequency transfer of the staphylococcal pathogenicity islands, showing that such antibiotics may have the unintended consequence of promoting the spread of bacterial virulence factors.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Penades, Prof Jose R |
| Authors: | Maiques, E., Ubeda, C., Campoy, S., Salvador, N., Lasa, I., Novick, R.P., Barbe, J., and Penades, J.R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Journal of Bacteriology |
| ISSN: | 0021-9193 |
| ISSN (Online): | 1098-5530 |
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