Husmeier, D. and Wright, F. (2001) Probabilistic divergence measures for detecting interspecies recombination. Bioinformatics, 17(Sup 1), S123-S131. (doi: 10.1093/bioinformatics/17.suppl_1.S123)
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Abstract
This paper proposes a graphical method for detecting interspecies recombination in multiple alignments of DNA sequences. A fixed-size window is moved along a given DNA sequence alignment. For every position, the marginal posterior probability over tree topologies is determined by means of a Markov chain Monte Carlo simulation. Two probabilistic divergence measures are plotted along the alignment, and are used to identify recombinant regions. The method is compared with established detection methods on a set of synthetic benchmark sequences and two real-world DNA sequence alignments.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Husmeier, Professor Dirk |
| Authors: | Husmeier, D., and Wright, F. |
| College/School: | College of Science and Engineering > School of Mathematics and Statistics > Statistics |
| Journal Name: | Bioinformatics |
| ISSN: | 1367-4803 |
| ISSN (Online): | 1460-2059 |
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