Ashman, R.B., Vijayan, D. and Wells, C.A. (2011) IL-12 and related cytokines: function and regulatory implications in candida albicans infection. Clinical and Developmental Immunology, 2011, Art. 686597. (doi: 10.1155/2011/686597)
|
Text
85434.pdf - Published Version Available under License Creative Commons Attribution. 1MB |
Abstract
IL-12 is a cytokine with links to both innate and adaptive immunity systems. In mice, its deletion leads to acute susceptibility to oral infection with the yeast Candida albicans, whereas such mice are resistant to systemic disease. However, it is an essential component of the adaptive response that leads to the generation of Th1-type cytokine responses and protection against disseminated disease. This paper presents an overview of the role of IL-12 in models of systemic and mucosal infection and the possible relationships between them.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Wells, Dr Christine |
Authors: | Ashman, R.B., Vijayan, D., and Wells, C.A. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Clinical and Developmental Immunology |
Publisher: | Hindawi Publishing Corporation |
ISSN: | 1740-2522 |
ISSN (Online): | 1740-2530 |
Copyright Holders: | Copyright © 2011 The Authors |
First Published: | First published in Clinical and Developmental Immunology 2011:686597 |
Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record