Acoustically controlled enhancement of molecular sensing to assess oxidative stress in cells

Reboud, J. , Auchinvole, C., Syme, C.D. , Wilson, R. and Cooper, J.M. (2013) Acoustically controlled enhancement of molecular sensing to assess oxidative stress in cells. Chemical Communications, 49(28), pp. 2918-2920. (doi: 10.1039/C3CC37931K)

85141.pdf - Accepted Version



We demonstrate a microfluidic platform for the controlled aggregation of colloidal silver nanoparticles using surface acoustic waves (SAWs), enabling surface enhanced Raman scattering (SERS) analysis of a cell based model for oxidative damage. We show that by varying the frequency and the power of the acoustic energy, it is possible to modulate the aggregation of the colloid within the sample and hence to optimise the SERS analysis.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Wilson, Dr Robert and Syme, Dr Christopher and Cooper, Professor Jonathan and Reboud, Dr Julien and Auchinvole, Dr Craig
Authors: Reboud, J., Auchinvole, C., Syme, C.D., Wilson, R., and Cooper, J.M.
Subjects:Q Science > QC Physics
T Technology > TK Electrical engineering. Electronics Nuclear engineering
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
College of Science and Engineering > School of Chemistry
Journal Name:Chemical Communications
Journal Abbr.:Chem. Comm.
Publisher:Royal Society of Chemistry
ISSN (Online):1364-548X
Copyright Holders:Copyright © 2013 Royal Society of Chemistry
First Published:First published in Chemical Communications 49(28):2918-2920
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
436881The molecular noseAndrew PittEngineering & Physical Sciences Research Council (EPSRC)EP/E032745/1RI MOLECULAR CELL & SYSTEMS BIOLOGY
553521Next Generation Analytical Tools: Application to Protein Oxidations that affect Human Health and WellbeingJonathan CooperEngineering & Physical Sciences Research Council (EPSRC)EP/I017887/1ENG - BIOMEDICAL ENGINEERING