attract: a method for identifying core pathways that define cellular phenotypes

Mar, J.C., Matigian, N.A., Quackenbush, J. and Wells, C.A. (2011) attract: a method for identifying core pathways that define cellular phenotypes. PLoS ONE, 6(10), e25445. (doi: 10.1371/journal.pone.0025445) (PMID:22022396) (PMCID:PMC3194807)

Abstract

attract is a knowledge-driven analytical approach for identifying and annotating the gene-sets that best discriminate between cell phenotypes. attract finds distinguishing patterns within pathways, decomposes pathways into meta-genes representative of these patterns, and then generates synexpression groups of highly correlated genes from the entire transcriptome dataset. attract can be applied to a wide range of biological systems and is freely available as a Bioconductor package and has been incorporated into the MeV software system.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Wells, Dr Christine
• Authors: Mar, J.C., Matigian, N.A., Quackenbush, J., and Wells, C.A.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: PLoS ONE
• Publisher: Public Library of Science
• ISSN: 1932-6203
• ISSN (Online): 1932-6203
• Copyright Holders: Copyright © 2011 The Authors
• First Published: First Published in PLoS One 6(10):e25445
• Publisher Policy: Reproduced under a Creative Commons License