Tribbles in acute leukemia

Liang, K.L., Rishi, L. and Keeshan, K. (2013) Tribbles in acute leukemia. Blood, 121(21), pp. 4265-4270. (doi: 10.1182/blood-2012-12-471300)

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There is growing research interest in the mammalian Tribbles (Trib) family of serine/threonine pseudokinases and their oncogenic association with acute leukemias. This review is to understand the role of Trib genes in hematopoietic malignancies and their potential as targets for novel therapeutic strategies in acute myeloid leukemia and acute lymphoblastic leukemia. We discuss the role of Tribs as central signaling mediators in different subtypes of acute leukemia and propose that inhibition of dysregulated Trib signaling may be therapeutically beneficial.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Keeshan, Dr Karen
Authors: Liang, K.L., Rishi, L., and Keeshan, K.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Blood
Publisher:American Society of Hematology
ISSN (Online):1528-0020

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