The effect of fibrinogen genotype on fibrinogen levels after strenuous physical exercise

Brull, D.J., Dhamrait, S., Moulding, R., Rumley, A., Lowe, G.D.O., World, M.J., Humphries, S.E. and Montgomery, H.E. (2002) The effect of fibrinogen genotype on fibrinogen levels after strenuous physical exercise. Thrombosis and Haemostasis, 87(1), pp. 37-41.

Abstract

We have examined the effect of two beta-fibrinogen gene promoter polymorphisms (-455G>A and -854G>A) on the Fibrinogen response to severe exercise in a croup of male army recruits undergoing basic training. Fibrinogen was measured pre-training and again serially after severe 48 h final military exercise (FME). Out of 884 subjects, 762 completed training of whom 250 were selected for post-FME study. Fibrinogen levels (g/l) were significantly elevated over baseline levels 2, 48 and 96 h after FME, representing increases of 15.7%, 3.4% and 7.6% (p lt 0.005; p = 0.05 and p lt 0.005 respectively), with higher levels in -455A allele carriers than genotype -455GG: 3.17 +/- 0.05 vs. 2.94 +/- 0.05 (p lt 0.001), 2.86 +/- 0.05 vs. 2.60 +/- 0.05 (p lt 0.0005) and 2.98 +/- 0.06 vs. 2.69 +/- 0.06 (p lt 0.0005) at 2, 48 and 96 h respectively. There was no effect of the -854G>A polymorphism on fibrinogen, even after taking, into account beta-fibrinogen -455 genotype. Thus the fibrinogen -455G>A polymorphism influences fibrinogen levels following exercise. The effect of genotype might be clinically relevant at times of hyperfibrinogenaemia such as following an acute inflammatory response.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Rumley, Dr Ann and Lowe, Professor Gordon
• Authors: Brull, D.J., Dhamrait, S., Moulding, R., Rumley, A., Lowe, G.D.O., World, M.J., Humphries, S.E., and Montgomery, H.E.
• Subjects: R Medicine > RC Internal medicine; Q Science > QP Physiology
• College/School: College of Medical Veterinary and Life Sciences; College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Thrombosis and Haemostasis
• ISSN: 0340-6245