Hudson, B.D. et al. (2013) Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor. Journal of Biological Chemistry, 288(24), pp. 17296-17312. (doi: 10.1074/jbc.M113.455337)
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Abstract
Background: Understanding the function of FFA2 has been slowed by a lack of selective orthosteric ligands. Results: Residues within FFA2 that dictate the recognition and function of potent and selective orthosteric agonists are described. Conclusion: Key aspects of ligand interaction with the orthosteric binding pocket of FFA2 are defined. Significance: This work will be invaluable in future drug development at the FFA2 receptor.
| Item Type: | Articles |
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| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Ward, Dr Richard and Marquez, Dr Rudi and Hudson, Dr Brian and Murdoch, Dr Hannah and Milligan, Professor Graeme |
| Authors: | Hudson, B.D., Due-Hansen, M.E., Christiansen, E., Hansen, A.M., Mackenzie, A.E., Murdoch, H., Pandey, S.K., Ward, R.J., Marquez, R., Tikhonova, I.G., Ulven, T., and Milligan, G. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences College of Science and Engineering > School of Chemistry |
| Journal Name: | Journal of Biological Chemistry |
| Publisher: | American Society for Biochemistry and Molecular Biology, Inc. |
| ISSN: | 0021-9258 |
| ISSN (Online): | 1083-351X |
| Copyright Holders: | Copyright © 2013 The The American Society for Biochemistry and Molecular Biology, Inc. |
| First Published: | First published in Journal of Biological Chemistry 288(24):17296-17312 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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