Parker, A.C., Pritchard, P., Preston, T. and Choonara, I. (1998) Induction of CYP1A2 activity by carbamazepine in children using the caffeine breath test. British Journal of Clinical Pharmacology, 45(2), pp. 176-178. (doi: 10.1046/j.1365-2125.1998.00684.x)
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Publisher's URL: http://dx.doi.org/10.1046/j.1365-2125.1998.00684.x
Abstract
<b>Aims</b>: Carbamazepine is a known enzyme inducer. The aim of this study was to determine whether carbamazepine induces the metabolism of caffeine in children. <b>Methods</b>: Children due to receive carbamazepine for epilepsy were recruited into the study. The caffeine breath test was carried out prior to the administration of carbamazepine and after a minimum of 2–3 weeks therapy. Five children were studied and they received 200–600 mg carbamazepine daily. <b>Results</b> The mean values of the 2 h cumulative labelled carbon dioxide were 3.47% before and 7.65% during carbamazepine. There was a significant increase in the percentage labelled caffeine exhaled as carbon dioxide during the administration of carbamazepine (Student's paired t-test, P<0.05). <b>Conclusions</b>: The results suggest that carbamazepine induces the metabolism of caffeine by the CYP1A2 pathway in the children studied.
Item Type: | Articles |
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Keywords: | Caffeine, carbamazepine, children, caffeine breath test, enzyme induction, CYP1A2 |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Preston, Professor Tom |
Authors: | Parker, A.C., Pritchard, P., Preston, T., and Choonara, I. |
Subjects: | Q Science > QH Natural history > QH345 Biochemistry |
College/School: | College of Science and Engineering > Scottish Universities Environmental Research Centre |
Journal Name: | British Journal of Clinical Pharmacology |
Journal Abbr.: | Br. J. Clin. Pharmacol. |
ISSN: | 0306-5251 |
ISSN (Online): | 1365-2125 |
Published Online: | 04 January 2002 |
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