Hewitt, J.F.M., Williams, L., Aggarwal, P., Smith, C.D. and France, D.J. (2013) Palladium-catalyzed heteroallylation of unactivated alkenes – synthesis of citalopram. Chemical Science, 4, pp. 3538-3543. (doi: 10.1039/C3SC51222C)
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Abstract
A palladium-catalyzed difunctionalization of unactivated alkenes with tethered nucleophiles is reported. The versatile reaction occurs with simple allylic halides and can be carried out under air. The methodology provides rapid access to a wide array of desirable heterocyclic targets, as illustrated by a concise synthesis of the widely prescribed antidepressant citalopram.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Aggarwal, Dr Pooja and France, Dr David |
| Authors: | Hewitt, J.F.M., Williams, L., Aggarwal, P., Smith, C.D., and France, D.J. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Chemical Science |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 2041-6520 |
| ISSN (Online): | 2041-6539 |
| Copyright Holders: | Copyright © 2013 The Royal Society of Chemistry |
| First Published: | First published in Chemical Science 4:3568-3543 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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