Late endosomal and lysosomal trafficking during integrin-mediated cell migration and invasion

Rainero, E. and Norman, J.C. (2013) Late endosomal and lysosomal trafficking during integrin-mediated cell migration and invasion. BioEssays, 35(6), pp. 523-532. (doi:10.1002/bies.201200160)

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Abstract

Recently it has become clear that trafficking of integrins to late endosomes is key to the regulation of integrin expression and function during cell migration. Here we discuss the molecular machinery that dictates whether integrins are sorted to recycling endosomes or are targeted to late endosomes and lysosomes. Integrins and other receptors that are sorted to late endosomes are not necessarily degraded and, under certain circumstances, can be spared destruction and returned to the cell surface to drive cell migration and invasion. We will discuss how the exchange of adhesion receptors and other key regulators of cell migration between late endosomes/lysosomes and the plasma membrane can promote dynamic turnover of adhesions during cell migration.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Norman, Professor James and Rainero, Ms Elena
Authors: Rainero, E., and Norman, J.C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:BioEssays
ISSN:0265-9247

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