Preliminary genetic analyses of important musculoskeletal conditions of thoroughbred racehorses in Hong Kong

Welsh, C.E. , Lewis, T.W., Blott, S.C., Mellor, D.J. , Lam, K.H., Stewart, B.D. and Parkin, T.D.H. (2013) Preliminary genetic analyses of important musculoskeletal conditions of thoroughbred racehorses in Hong Kong. Veterinary Journal, 198(3), pp. 611-615. (doi: 10.1016/j.tvjl.2013.05.002) (PMID:23746478) (PMCID:PMC3899015)

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A retrospective cohort study of important musculoskeletal conditions of Thoroughbred racehorses was conducted using health records generated over a 15 year period (n = 5062, 1296 sires). The prevalence of each condition in the study population was: fracture, 13%; osteoarthritis, 10%; suspensory ligament injury, 10%; and tendon injury, 19%. Linear and logistic sire and animal regression models were built to describe the binary occurrence of these musculoskeletal conditions, and to evaluate the significance of possible environmental risk factors. The heritability of each condition was estimated using residual maximum likelihood (REML). Bivariate mixed models were used to generate estimates of genetic correlations between each pair of conditions.<p></p> Heritability estimates of fracture, osteoarthritis, suspensory ligament and tendon injury were small to moderate (range: 0.01–0.20). Fracture was found to be positively genetically correlated with both osteoarthritis and suspensory ligament injury. These results suggest that there is a significant genetic component involved in the risk of the studied conditions. Due to positive genetic correlations, a reduction in prevalence of one of the correlated conditions may effect a reduction in risk of the other condition.<p></p>

Item Type:Articles
Glasgow Author(s) Enlighten ID:Parkin, Professor Tim and Mellor, Professor Dominic and Welsh, Dr Claire
Authors: Welsh, C.E., Lewis, T.W., Blott, S.C., Mellor, D.J., Lam, K.H., Stewart, B.D., and Parkin, T.D.H.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Veterinary Journal
ISSN (Online):1532-2971
Published Online:05 June 2013
Copyright Holders:Copyright © 2013 Elsevier
First Published:First published in Veterinary Journal
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
500192BBSRC Doctoral Training Grant 2009-15Massimo PalmariniBiotechnology and Biological Sciences Research Council (BBSRC)BB/F016786/1MVLS III - CENTRE FOR VIRUS RESEARCH