Biochemical and immunological characterization of toxoplasma gondii macrophage migration inhibitory factor

Sommerville, C., Richardson, J.M., Williams, R.A.M., Mottram, J.C. , Roberts, C.W., Alexander, J. and Henriquez, F.L. (2013) Biochemical and immunological characterization of toxoplasma gondii macrophage migration inhibitory factor. Journal of Biological Chemistry, 288(18), pp. 12733-12741. (doi: 10.1074/jbc.M112.419911)

Abstract

<p>Background: Toxoplasma gondii possesses proteins that can modulate host immune responses. TgMIF is a homologue of mammalian macrophage migration inhibitory factor.</p> <p>Results: TgMIF possesses tautomerase but not oxidoreductase activity. It can stimulate ERK MAPK and IL-8 production.</p> <p>Conclusion: TgMIF is capable of modulating host molecules.</p> <p>Significance: The study identifies immunomodulatory activity of TgMIF consistent with a role for sustaining parasite survival.</p>

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Williams, Mr Roderick and Mottram, Professor Jeremy
• Authors: Sommerville, C., Richardson, J.M., Williams, R.A.M., Mottram, J.C., Roberts, C.W., Alexander, J., and Henriquez, F.L.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Journal of Biological Chemistry
• Publisher: American Society for Biochemistry and Molecular Biology, Inc.
• ISSN: 0021-9258
• ISSN (Online): 1083-351X
• Copyright Holders: Copyright © 2013 American Society for Biochemistry and Molecular Biology, Inc.
• First Published: First published in Journal of Biological Chemistry 288(18):12733-12741
• Publisher Policy: Reproduced under a Creative Commons License