Hankey, G. J. et al. (2012) Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: results of a randomized placebo-controlled trial. Stroke, 43(6), pp. 1572-1577. (doi: 10.1161/STROKEAHA.111.641613)
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Publisher's URL: http://dx.doi.org/10.1161/STROKEAHA.111.641613
Abstract
<p>Background and Purpose—To determine the effect of B vitamin treatment on the incidence of cancer among patients with stroke or transient ischemic attack.</p> <p>Methods—A total of 8164 patients with recent stroke or transient ischemic attack were randomly allocated to double-blind treatment with 1 tablet daily of placebo or B vitamins (2 mg folic acid, 25 mg vitamin B6, 500 μg vitamin B12) and followed for a median of 3.4 years for any cancer as an adverse event.</p> <p>Results—There was no significant difference in the incidence of any cancer among participants assigned B vitamins compared with placebo (4.04% versus 4.59%; risk ratio, 0.86; 95% CI, 0.70–1.07) and no difference in cancer mortality (2.35% versus 2.09%; risk ratio, 1.09; 0.81–1.46). Among 1899 patients with diabetes, the incidence of cancer was higher among participants assigned B vitamins compared with placebo (5.35% versus 3.28%; adjusted risk ratio, 2.21; 1.31–3.73), whereas among 6168 patients without diabetes, the incidence of cancer was lower among participants assigned B vitamins compared with placebo (3.66% versus 5.03%; adjusted risk ratio, 0.67; 0.51–0.87; P for interaction=0.0001).</p> <p>Conclusions—Daily administration of folic acid, vitamin B6, and vitamin B12 to 8164 patients with recent stroke or transient ischemic attack for a median of 3.4 years had no significant effect, compared with placebo, on cancer incidence or mortality. However, a post hoc subgroup analysis raises the hypothesis that folic acid treatment may increase the incidence of cancer among diabetics and reduce the incidence of cancer among nondiabetics with a history of stroke or transient ischemic attack.</p>
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Lees, Professor Kennedy |
| Authors: | Hankey, G. J., Eikelboom, J. W., Yi, Q., Lees, K. R., Chen, C., Xavier, D., Navarro, J. C., Ranawaka, U. K., Uddin, W., Ricci, S., Gommans, J., and Schmidt, R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Stroke |
| Publisher: | American Heart Association |
| ISSN: | 0039-2499 |
| ISSN (Online): | 1524-4628 |
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