Impact of Scotland’s comprehensive, smoke-free legislation on stroke

Mackay, D. F. , Haw, S., Newby, D. E., Langhorne, P. , Lloyd, S. M. , McConnachie, A. and Pell, J. P. (2013) Impact of Scotland’s comprehensive, smoke-free legislation on stroke. PLoS ONE, 8(5), e62597. (doi: 10.1371/journal.pone.0062597) (PMID:23667497) (PMCID:PMC3648581)

80737.pdf - Published Version
Available under License Creative Commons Attribution.


Publisher's URL:


<p>Background: Previous studies have reported a reduction in acute coronary events following smoke-free legislation. Evidence is lacking on whether stroke is also reduced. The aim was to determine whether the incidence of stroke, overalland by sub-type, fell following introduction of smoke-free legislation across Scotland on 26 March 2006.</p> <p>Methods and Findings: A negative binomial regression model was used to determine whether the introduction of smokefree legislation resulted in a step and/or slope change in stroke incidence. The model was adjusted for age-group, sex, socioeconomic deprivation quintile, urban/rural residence and month. Interaction tests were also performed. Routine hospital administrative data and death certificates were used to identify all hospital admissions and pre-hospital deaths due to stroke (ICD10 codes I61, I63 and I64) in Scotland between 2000 and 2010 inclusive. Prior to the legislation, rates of all stroke, intracerebral haemorrhage and unspecified stroke were decreasing, whilst cerebral infarction was increasing at 0.97% per annum. Following the legislation, there was a dramatic fall in cerebral infarctions that persisted for around 20 months. No visible effect was observed for other types of stroke. The model confirmed an 8.90% (95% CI 4.85, 12.77, p,0.001) stepwise reduction in cerebral infarction at the time the legislation was implemented, after adjustment for potential cofounders.</p> <p>Conclusions: Following introduction of national, comprehensive smoke-free legislation there was a selective reduction in cerebral infarction that was not apparent in other types of stroke.</p>

Item Type:Articles
Glasgow Author(s) Enlighten ID:Langhorne, Professor Peter and Mackay, Professor Daniel and Lloyd, Miss Suzanne and McConnachie, Professor Alex and Pell, Professor Jill
Authors: Mackay, D. F., Haw, S., Newby, D. E., Langhorne, P., Lloyd, S. M., McConnachie, A., and Pell, J. P.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health
College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre
Journal Name:PLoS ONE
Publisher:Public Library of Science
ISSN (Online):1932-6203
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in PLoS ONE 8(5):e62597
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record