Detecting sequence homology at the gene cluster level with MultiGeneBlast

Medema, M.H., Takano, E. and Breitling, R. (2013) Detecting sequence homology at the gene cluster level with MultiGeneBlast. Molecular Biology and Evolution, 30(5), pp. 1218-1223. (doi: 10.1093/molbev/mst025)

Abstract

The genes encoding many biomolecular systems and pathways are genomically organized in operons or gene clusters. With MultiGeneBlast, we provide a user-friendly and effective tool to perform homology searches with operons or gene clusters as basic units, instead of single genes. The contextualization offered by MultiGeneBlast allows users to get a better understanding of the function, evolutionary history, and practical applications of such genomic regions. The tool is fully equipped with applications to generate search databases from GenBank or from the user’s own sequence data. Finally, an architecture search mode allows searching for gene clusters with novel configurations, by detecting genomic regions with any user-specified combination of genes.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Breitling, Professor Rainer
• Authors: Medema, M.H., Takano, E., and Breitling, R.
• College/School: College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
• Journal Name: Molecular Biology and Evolution
• Publisher: Oxford University Press
• ISSN: 0737-4038
• ISSN (Online): 1537-1719
• Copyright Holders: Copyright © 2013 The Authors
• First Published: First published in Molecular Biology and Evolution 30(5):1218-1223
• Publisher Policy: Reproduced under a Creative Commons License