Enhanced in vivo immune responses to bacterial lipopolysaccharide by exogenous CD40 stimulation

Barr, T.A. and Heath, A.W. (1999) Enhanced in vivo immune responses to bacterial lipopolysaccharide by exogenous CD40 stimulation. Infection and Immunity, 67(7), pp. 3637-3640.

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Publisher's URL: http://iai.asm.org/content/67/7/3637

Abstract

The lack of specific T-cell help in immune responses to thymus-independent antigens results in weak, predominantly immunoglobulin M-mediated immunity with little or no memory. In the work presented here we show how the exogenous stimulation of CD40 by monoclonal antibodies can mimic T-cell help, resulting in enhanced immune responses which are protective against bacterial infection.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Barr, Dr Tom
Authors: Barr, T.A., and Heath, A.W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Infection and Immunity
ISSN:0019-9567
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