Innate responses of B cells

Gray, D., Gray, M. and Barr, T. (2007) Innate responses of B cells. European Journal of Immunology, 37(12), pp. 3304-3310. (doi: 10.1002/eji.200737728)

Abstract

In this review, we describe the non-antibody-mediated functions of B cells within the immune system. In addition to antibody production, B cells also present antigen to T cells, programme T cell differentiation and regulate effector T cell responses and much of this is mediated by the cytokines they make. We focus on the potential of B cells to perform these functions simply as a result of activation via ‘innate’ receptors (e.g. Toll-like receptors) and often independently of BCR ligation. We feel an appreciation of these broad and often antigen-nonspecific functions is important at a time when there is an increasing use of B cell depletion as a therapy for autoimmune disease.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Barr, Dr Tom
• Authors: Gray, D., Gray, M., and Barr, T.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: European Journal of Immunology
• ISSN: 0014-2980