Posttranslational modifications of GLUT4 affect its subcellular localization and translocation

Sadler, J. B.A., Bryant, N. J., Gould, G. W. and Welburn, C. R. (2013) Posttranslational modifications of GLUT4 affect its subcellular localization and translocation. International Journal of Molecular Sciences, 14(5), pp. 9963-9978. (doi: 10.3390/ijms14059963) (PMID:23665900) (PMCID:PMC3676823)

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The facilitative glucose transporter type 4 (GLUT4) is expressed in adipose and muscle and plays a vital role in whole body glucose homeostasis. In the absence of insulin, only ~1% of cellular GLUT4 is present at the plasma membrane, with the vast majority localizing to intracellular organelles. GLUT4 is retained intracellularly by continuous trafficking through two inter-related cycles. GLUT4 passes through recycling endosomes, the trans Golgi network and an insulin-sensitive intracellular compartment, termed GLUT4-storage vesicles or GSVs. It is from GSVs that GLUT4 is mobilized to the cell surface in response to insulin, where it increases the rate of glucose uptake into the cell. As with many physiological responses to external stimuli, this regulated trafficking event involves multiple posttranslational modifications. This review outlines the roles of posttranslational modifications of GLUT4 on its function and insulin-regulated trafficking.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Gould, Professor Gwyn and Sadler, Miss Jessica and Bryant, Dr Nia and Welburn, Dr Cassie
Authors: Sadler, J. B.A., Bryant, N. J., Gould, G. W., and Welburn, C. R.
College/School:College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
Journal Name:International Journal of Molecular Sciences
ISSN (Online):1422-0067
Published Online:10 May 2013
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in International Journal of Molecular Sciences 14(5):9963-9978
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
578371Role of ubiquitination as a transient modification in regulated protein traffickingNia BryantMedical Research Council (MRC)MR/J000221/1RI MOLECULAR CELL & SYSTEMS BIOLOGY
556381v-SNARE requirements for entry of GLUT4 into the insulin-responsive compartmentGwyn GouldDiabetes UK (DIABETESUK)10/0004126RI MOLECULAR CELL & SYSTEMS BIOLOGY