Synthesis of an amino acid based phosphodiester linkage containing cryptand

van Oijen, A.H., de Bont, H.B.A., van Boom, J.H. and Liskamp, R.M.J. (1991) Synthesis of an amino acid based phosphodiester linkage containing cryptand. Tetrahedron Letters, 32(52), pp. 7723-7726. (doi: 10.1016/0040-4039(91)80575-Q)

Abstract

The synthesis of an amino acid based phosphodiester linkage containing cryptand is described. The macrocyclic ring is constructed using Boc-L-Ser(OBn)-OH, Boc-D-Ser(OBn)-OH, diethylene glycol and ethylene dioxydiacetic acid. The phosphodiester linkage was introduced employing 4-chlorobenzyl dichlorophosphite leading to the cryptand.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Liskamp, Professor Robert
• Authors: van Oijen, A.H., de Bont, H.B.A., van Boom, J.H., and Liskamp, R.M.J.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Tetrahedron Letters
• ISSN: 0040-4039