Moree, W.J., van der Marel, G.A., van Boom, J.H. and Liskamp, R.M.J. (1993) Peptides containing the novel methylphosphinamide transition-state isostere. Tetrahedron, 49(47), pp. 11055-11064. (doi: 10.1016/S0040-4020(01)80258-1)
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Publisher's URL: http://dx.doi.org/10.1016/S0040-4020(01)80258-1
Abstract
A convenient route towards the synthesis of peptides containing the methylphosphinamide moiety as a novel transition-state isostere of the amide bond hydrolysis is described. The key step being the coupling of a methylphosphinic chloride with an amino acid or peptide protected at the C-terminus. A proper choice of the amino protecting group appeared to be essential.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Liskamp, Professor Robert |
| Authors: | Moree, W.J., van der Marel, G.A., van Boom, J.H., and Liskamp, R.M.J. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Tetrahedron |
| ISSN: | 0040-4020 |
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