Solid-phase synthesis of peptidosulfonamide containing peptides derived from Leu-enkephalin

de Bont, D.B.A., Dijkstra, G.D.H., den Hartog, J.A.J. and Liskamp, R.M.J. (1996) Solid-phase synthesis of peptidosulfonamide containing peptides derived from Leu-enkephalin. Bioorganic and Medicinal Chemistry Letters, 6(24), pp. 3035-3040. (doi: 10.1016/S0960-894X(96)00565-3)

Abstract

Using Boc or Fmoc-protected β-substituted aminoethanesulfonyl chlorides (2-substituted taurylchlorides) the solid-phase synthesis of dipeptidosulfonamides as well as peptidosulfonamide containing peptides derived from Leu-enkephalin is described. The binding activity of the peptidosulfonamide YGGFL derivatives is reported.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Liskamp, Professor Robert
• Authors: de Bont, D.B.A., Dijkstra, G.D.H., den Hartog, J.A.J., and Liskamp, R.M.J.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Bioorganic and Medicinal Chemistry Letters
• ISSN: 0960-894X
• ISSN (Online): 1464-3405